Holotranscobalamin as an indicator of dietary vitamin B12 deficiency.
نویسندگان
چکیده
B12 Deficiency, Zouë Lloyd-Wright, 1 Anne-Mette Hvas, Jan Møller, Tom A.B. Sanders, and Ebba Nexø ( Nutrition Food & Health Research Centre, King’s College London, Franklin-Wilkins Bldg., 150 Stamford St., Waterloo, London SE1 9NN, United Kingdom; 2 Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK8000 Aarhus C, Denmark; 3 Department of Clinical Biochemistry, SKS, Aarhus University Hospital, DK-8200 Aarhus N, Denmark; * author for correspondence: fax 44-207-848-4171, e-mail [email protected])
منابع مشابه
Holotranscobalamin (HoloTC, Active-B12) and Herbert’s model for the development of vitamin B12 deficiency: a review and alternative hypothesis
The concentration of total vitamin B12 in serum is not a sufficiently sensitive or specific indicator for the reliable diagnosis of vitamin B12 deficiency. Victor Herbert proposed a model for the staged development of vitamin B12 deficiency, in which holotranscobalamin (HoloTC) is the first indicator of deficiency. Based on this model, a commercial immunoassay has been controversially promoted ...
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Vitamin B12 (cobalamin) is an essential coenzyme for nucleic acid synthesis. Animal protein is the major dietary source of vitamin B12. Deficiency of vitamin B12 leads to megaloblastic anemia, degeneration of the brain, spinal cord, peripheral nerves, and abnormalities of epithelial tissues. Two factors are necessary for the cure of megaloblastic anemia: one in food (extrinsic factor) and one i...
متن کاملMeasurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency.
BACKGROUND The standard screening test for vitamin B12 deficiency, measurement of total plasma vitamin B12, has limitations of sensitivity and specificity. Plasma vitamin B12 bound to transcobalamin (holoTC) is the fraction of total vitamin B12 available for tissue uptake and therefore has been proposed as a potentially useful alternative indicator of vitamin B12 status. METHODS We compared t...
متن کاملAnaemia and Haemoglobinuria Holotranscobalamin – An Early Marker for Laboratory Diagnosis of Vitamin B12 Deficiency
Vitamin B12 deficiency is widespread. Among the population groups at risk are older people, vegetarians, pregnant women and patients with renal or intestinal diseases. The neurological symptoms of vitamin B12 deficiency are unspecific and can be irreversible. Early detection is therefore important. This article reviews the diagnostic performance of the different laboratory markers for vitamin B...
متن کاملAlgorithm for the early diagnosis of vitamin B12 deficiency in elderly people.
BACKGROUND The elderly population is particularly at risk for developing vitamin B12-deficiency. Serum cobalamin does not necessarily reflect a normal B12 status. The determination of methylmalonic acid is not available in all laboratories. Issues of sensitivity for holotranscobalamin and the low specificity of total homocysteine limit their utility. The aim of the present study is to establish...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 49 12 شماره
صفحات -
تاریخ انتشار 2003